Sedative Tolerance Accompanies Tolerance to the Analgesic Effects of Fentanyl in Infant Rats
نویسندگان
چکیده
منابع مشابه
Voluntary and forced exercises prevent the development of tolerance to analgesic effects of morphine in rats
Objective(s):Morphine is widely used to treat chronic pain. However, its utility is hindered by the development of tolerance to its analgesic effects. Despite the renowned beneficial effects of physical exercise on cognitive functions and signs of morphine withdrawal in morphine-dependent rats, little is known about the roles of voluntary and forced exercises in tolerance to analgesic effect of...
متن کاملRepeated injections of orexin-A developed behavioral tolerance to its analgesic effects in rats
Objective(s):Reduction of pharmacological effectiveness or tolerance appears following repeated administration of many analgesic drugs. We investigated tolerance to anti-nociceptive effects of orexin-A, an endogenous potent analgesic peptide using the hot-plate test.Materials and Methods:Orexin-A was microinjected ICV (intracerebroventricular) with an interval of 12 hr for 7 continuous days and...
متن کاملIntrathecal administration of epinephrine inhibits and reverses analgesic tolerance to analgesic effect of morphine in rats
Introduction: Several researches have reported that stress is able to inhibit the development of morphine tolerance via activating of Hypothalamic-Pituitary-Adrenal (HPA) axis. In the present study we tried to examine the effect of epinephrine, the product of adrenal medulla, on the development of morphine tolerance. Methods: Analgesic tolerance was induced by intrathecal (i.t.) injection of...
متن کاملEffects of Papaver rhoeas Extract on the Tolerance Development to Analgesic Effects of Morphine in Mice
Previous studies have shown that the extract of Papaver rhoeas reduces morphine dependence, locomotor activity and reward. In present study, the effects of hydro-alcohol extract of Papaver Rhoeas on the tolerance to analgesic effects of morphine in mice have been investigated using tail flick method. Subcutaneous (s.c.) administration of morphine (1, 2, 5 and 10 mg/kg) induced analgesia. Howeve...
متن کاملEffects of Papaver rhoeas Extract on the Tolerance Development to Analgesic Effects of Morphine in Mice
Previous studies have shown that the extract of Papaver rhoeas reduces morphine dependence, locomotor activity and reward. In present study, the effects of hydro-alcohol extract of Papaver Rhoeas on the tolerance to analgesic effects of morphine in mice have been investigated using tail flick method. Subcutaneous (s.c.) administration of morphine (1, 2, 5 and 10 mg/kg) induced analgesia. Howeve...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pediatric Research
سال: 2000
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-200006000-00008